In this resource, participants will learn how the guiding principles of Universal Design for Learning (UDL) and Quality Matters (QM) can be used together to enhance online virtual and blended learning. Within this resource the authors present complimentary ideas to enhance online learning, including the leading elements from a set of practical UDL and QM principles. This resource presents useful online learning strategies for implementation in a point/counter-point style. The goal is to demonstrate how UDL and QM principles relate well in designing online courses. Readers will learn more about UDL and QM principles so they can apply these ideas to their online courses in areas such as course (1) background/context, (2) design, (3) content, (4) feedback, and (5) student interaction.